49ers, Tennessee Titans
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The Tennessee Titans had no answer for Brock Purdy and the San Francisco offense in a Week 15, 37-24, loss to the 49ers .
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Titans continue years-long streak of futility in loss to 49ers
The Tennessee Titans fell to 2-12 to the San Francisco 49ers (10-4) in Week 15 by a score of 37-24. The latest loss came one week after Tennessee won for only the second time this season on the road against the Cleveland Browns (3-11).
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Preview the San Francisco 49ers' NFL week 15 matchup with the Titans, including betting odds, tips, trends, and game information.
Jeffery Simmons made a remarkable impact for the Tennessee Titans in their 37-24 loss to San Francisco on Sunday.
The San Francisco 49ers will look to continue their push for the NFL playoffs when they host the Tennessee Titans on Sunday. San Francisco (9-4) is hot on the tails of the Los Angeles Rams and Seattle Seahawks in the NFC West, while Tennessee (2-11) is in contention to earn the first overall pick in next year's NFL Draft.
The Tennessee Titans are back in the loss column after falling 37-24 to the San Francisco 49ers in Week 15 at Levi's Stadium. The Titans were trailing for the entire game against the Niners, but they had a good fight against the Niners.
See the Titans vs 49ers game stats from the 37-24 loss on Dec. 14, 2025, including match player stats and team stats.