NFL MNF shakeup as the 49ers rout the Colts, helping the Jaguars, Chargers, and Bills officially clinch playoff spots in a pivotal Week 16.

The Bills had the best rushing attack in the NFL this year with an average of 159.6 yards per game. Only one other team in the NFL even topped145 yards per game during the regular season. The Bills went 9-0 in games where they rushed for at least 150 yards thanks in large part to their not-so-secret weapon, James Cook.

Josh Allen and the Buffalo Bills extended their hot stretch to four straight wins Sunday, coming from behind to defeat the Cleveland Browns 23-20 at Huntington Bank Field. Running back James Cook rushed for 117 yards and two touchdowns, leading the ground attack and helping Buffalo rally in the second half.

Tom Brady joins Colin Cowherd to preview 49ers vs. Eagles, discuss his favorite playoff memories, whether or not it’s Super Bowl or Bust for the Buffalo Bills, and if Matthew Stafford or Drake Maye deserves the MVP.

Nick Wright unveils his NFL Tiers going into Week 18 and 2026, featuring the Jacksonville Jaguars, Buffalo Bills and San Francisco 49ers.

San Francisco 49ers left tackle Trent Williams and wide receiver Ricky Pearsall did not participate in practice on Wednesday. Williams has been dealing with a hamstring injury, while Pearsall has been hampered by knee and ankle injuries.

What could NFL playoff bracket look like in divisional round? NFC playoff game scenarios for Seahawks, Bears, Eagles, Panthers, Rams, 49ers, Packers.

The Bills weren’t in action on Monday night, but they did secure a postseason berth. “Monday Night Football” featured the Colts hosting the 49ers, and San Francisco got the better of Indianapolis, 48-27. With the Colts’ loss, the Bills have secured ...

The Buffalo Bills have a unicorn at quarterback in Josh Allen. Since his arrival in the league, he's ascended to one of the very best at his position and has become a saving grace in Buffalo. Before Allen arrived,