Appendectomy may lead to harmful changes in the gut microbiome that contribute to colorectal cancer (CRC), a new report from China suggests. In one part of a three-part analysis, researchers observed ...

Cancer research is more than just the study of diagnostics and novel therapies. Researchers also investigate the causes of cancer, be they small or, in this case, vestigial. The appendix has long been ...

Please provide your email address to receive an email when new articles are posted on . About one-third of children treated with antibiotics for appendicitis experienced treatment failure. Children in ...

Ten-year follow-up results showed that 37.8% of patients who received antibiotics versus appendectomy had a true recurrence of appendicitis. Overall, cumulative complication rates at 10 years were ...

Antibiotic management of acute uncomplicated appendicitis among children was inferior to appendectomy, a randomized non-inferiority trial showed. For nearly 850 children with available primary outcome ...

Appendicitis. Illustration of a human appendix, showing it red and inflamed in appendicitis. The appendix is a narrow finger-shaped tube that branches off the first part of the large intestine (caecum ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they ...

We conducted a pragmatic, nonblinded, noninferiority, randomized trial comparing antibiotic therapy (10-day course) with appendectomy in patients with appendicitis at 25 U.S. centers. The primary ...

For patients who received antibiotics for uncomplicated acute appendicitis, rates of recurrence and subsequent appendectomy at 10 years indicated that the strategy is a safe and feasible alternative ...