Alcohol binge increases intestinal permeability by activating intestinal epithelial CB1R-ERK1/2 signalling with subsequently reduced differentiation and downregulation of tight junctions (left).
Heavy alcohol consumption is a leading cause of gastrointestinal diseases, with binge drinking linked to increased intestinal permeability-a condition commonly known as "leaky gut." Despite the ...
CB1R also was found to modulate alcohol-induced liver fibrosis. 39 A study conducted by Patsenker et al. observed a strong expression of CB1R in the fibrotic septa of patients with alcohol-associated ...
Researchers have made new progress in understanding how cannabinoid receptors (CB1Rs), the proteins that detect the active components of marijuana, are controlled in the brain. Researchers at the ...
Skye advances multiple ascending dose arm of SBI-100 Ophthalmic Emulsion trial San Diego, California--(Newsfile Corp. - May 17, 2023) - Skye Bioscience, Inc. (OTCQB: SKYE) ("Skye" or the "Company"), a ...
MONTREAL, Québec--(BUSINESS WIRE)--Inversago Pharma Inc. (“Inversago”), a leader in the development of peripherally-acting CB1 receptor blockers to address complications associated with metabolic and ...
A major challenge in neuroscience lies in understanding how molecular and circuit differences in the brain synergistically contribute to sex differences in behavioral phenotypes. Sex differences in ...
Researchers report that alterations in a molecular brain pathway activated by marijuana, called cannabinoid 1 receptor, may contribute to the cognitive symptoms of schizophrenia, suggesting possible ...
Researchers at the University of Bristol have made new progress in understanding how cannabinoid receptors (CB1Rs), the proteins that detect the active components of marijuana, are controlled in the ...
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