The team hypothesized that PGE₂ acts on the lateral parabrachial nucleus (LPB) in the brain, which relays sensory signals, to trigger chills and warmth-seeking behaviors during infection. This was ...
Cold signals from skin sensory neurons are delivered to the CeA via the spinal cord and the LPB. PGE₂ acting on EP3R in the LPB amplifies these cold signals (pink pathway), enhancing cold sensitivity ...
When running a fever during infection, we often feel chills, which prompt us to take action to warm ourselves, such as turning on a heater or adding layers of clothing. Increased body temperature ...
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