Researchers utilized chameleonic tautomerism properties to derive 3-aminoindolines and 2’-aminoarylacetic acids from the same substrate 3-azido-2-hydroxyindolines and Grignard reagent via ...

Making complicated organic molecules is like solving a Rubik’s cube. Organic chemists need to design sequences of reactions to carefully build up parts of a molecule, while maintaining the structure ...

During a symposium in June, the ACS Division of the History of Chemistry (HIST) awarded the Citation for Chemical Breakthrough to the University of Lyon, in France, in honor of the institution’s role ...

In 1912, Victor Grignard was awarded the Nobel Prize in Chemistry for his discovery of what came to be known as Grignard reagents. Since then, these compounds have come to play a key role in the ...

The reaction utilizes an iron catalyst together with an N-heterocyclic carbene (NHC) ligand, which suppresses unwanted side reactions to promote highly selective nucleophile addition. In organic ...

The Grignard reaction is a powerful, frequently used organometallic transformation to add important structural motifs to carbonyl compounds resulting in secondary or tertiary alcohols. Since usually ...

In this video I will be demonstrating the Grignard reaction to produce butyric acid. The Grignard reaction is a very interesting reaction which can be used to form new carbon-carbon bonds. The final ...

WeylChem has announced its intention to produce reagents on an industrial scale for major manufacturers of pharmaceuticals, agrochemicals and poly-functionalized products. A complete series of ...