UAB researchers discover that the immune system consistently targets the same region of mismatched HLA proteins after organ ...

One main goal of anti-cancer therapies is to kill tumor cells without affecting the surrounding normal cells. Therefore, many drugs are designed to target tumor-specific antigens, which are molecules ...

When a patient undergoes an organ transplant, failure to match the donor and recipient can lead to the recipient's immune system attacking the new organ, a process triggered by a specific HLA (human ...

Although drug eruptions are often linked to the human leukocyte antigen (HLA), the mechanism of its involvement in presenting symptoms of the skin remains unclear. In a recent study, researchers used ...

Human LAG-3 homodimer (with domains D1, D2, D3 and D4) binding to two separate HLA-II (MHC-II) molecules on the surface of an antigen-presenting cell (APC), imposing a distinct 38° offset angle. This ...

The advances in molecular biology and genomic sequencing have helped in significantly increasing the accuracy, speed, and efficiency of HLA typing. Most of the conventional methods of serological ...

Using genetically engineered mice expressing a specific variant of HLA, researchers uncover the instrumental role of this protein in the development of drug eruptions. They found that when HLA binds ...