The insulin and the IGF-1 pathway are closely intertwined. Both can bind the insulin receptor or the IGF receptor 1 (IGFR-1). IGF-2, on the other hand, can bind either IGFR-1 or the high-affinity IGFR ...
Nanomedsyn has described lysosome targeting chimeras (LYTACs) comprising cation-independent mannose-6-phosphate receptor (IGF-2R)-targeting glycosides covalently linked to TNF-α degradation inducers.
Dr. Gregory M. Cote: A 52-year-old man with a metastatic solitary fibrous tumor was admitted to this hospital because of recurrent episodes of hypoglycemia. The patient had been in his usual state of ...
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