Diabetes. 2006;56(3):594-603. Cellular and morphological characteristics of islets and quantification of cell death (including apoptosis and necrosis). For normoxic and hypoxic conditions, ...

BM stem cells may have regenerative effects on islet function through angiogenesis. Human islets (100 islet equivalent/mL) were cultured alone (control) or co-cultured (experimental group) with whole ...

Islet transplantation is a promising cellular replacement therapy for patients in severe diabetes with poor glucose control. This treatment is limited by the lack of a human donor pool 1, and ...

Wenzhou Medical University researchers have reimagined the spleen as a viable site for islet transplantation, enabling long-term diabetes control without the burden of full immunosuppression.

The currently approved islet-transplant method infuses islets into a vein in the liver. This invasive procedure requires the long-term use of immune-suppressing drugs to prevent islet rejection, ...

In 1993 the Diabetes Control and Complications Trial (DCCT) established the modern standard of care for the medical management of type 1 diabetes mellitus. 1 The DCCT randomly assigned 1441 patients ...

A vascularized organoid model of hormone-secreting cells in the pancreas has been developed, with potential to improve diabetes research and cell-based therapies. “Our results highlight the importance ...

In culture and after transplantation, the oxygen supply of islets and nutrients depends solely on diffusion. The pO 2 level may be sufficiently high throughout the transplanted islets to maintain cell ...

Adding engineered human blood vessel-forming cells to islet transplants boosted the survival of the insulin-producing cells and reversed diabetes in a preclinical study led by Weill Cornell Medicine ...