Scientists have zeroed in on a critical weak spot behind a rare but devastating brain autoimmune disorder often known as ...

Advancing a selective oral NMDA receptor modulator toward Phase 2a in chemotherapy-induced peripheral neuropathy following favorable Phase 1 safety and tolerability findings ...

The difference between mental health and mental illness can turn on changes in brain cells and their connections that are almost incomprehensibly tiny, at least in physical terms. This irony is ...

Postembedding immunogold labeling was used to determine the relationship between AMPA and NMDA receptor density and size of Schaffer collateral–commissural (SCC) synapses of the adult rat. All SCC ...

Glutamate is the main excitatory neurotransmitter in the mammalian CNS and mediates neurotransmission across most excitatory synapses. Three classes of glutamate-gated ion channels (AMPA, kainate and ...

Drugs that act on NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment consciousness, are key for treating neuropsychiatric disorders. These drugs were ...

It remains difficult to distinguish anti-NMDA receptor encephalitis from a primary psychiatric disorder, but recent studies have identified clinical features and proposed screening criteria that could ...

Researchers review the future of schizophrenia treatment, highlighting TAAR1 agonists, NMDA enhancers, and the gut-brain axis as key new frontiers.

Glutamate receptors at the postsynaptic membrane play important roles in neural plasticity. It is widely accepted that they either strengthen or weaken neurotransmission by allowing an influx of ...

One of several types of ligand-gated ion channel, the N-methyl-D-aspartate (NMDA) receptor transmits excitatory stimuli in the brain. When calcium flows through this channel, neural plasticity happens ...