Residual amount of phosphodiester from incomplete sulfurization and side reaction. A review by Goodchild eloquently summarizes the established technique for oligonucleotide synthesis which has been ...

Delivery to intracellular target sites is still one of the main obstacles in the development of peptide nucleic acids (PNAs) as antisense-antigene therapeutics. Here, we designed a self-assembled ...

Oligonucleotide therapeutics make up a small but rapidly growing segment of the overall global drug pipeline, with 245 programs currently in development today. While only one approved oligo ...

Conformational cooperativity is a universal molecular effect mechanism and plays a critical role in signaling pathways. However, it remains a challenge to develop artificial molecular networks ...

Oligonucleotides – short, synthetic sequences of DNA or RNA – have evolved from basic lab reagents to powerful enablers of precision medicine. Once confined to PCR primers and hybridization probes, ...