Potential drugs that seem promising in the lab, but don't show any activity in a person: they cost the industry an incredible amount of time and money. That's why Indira Nederpelt focuses on a more ...

Determination of accurate binding kinetics and affinity along with other critical quality attributes (CQAs) plays an ever-increasingly important role in identifying and isolating therapeutic molecules ...

Motor protein motion on biopolymers can be described by models related to the totally asymmetric simple exclusion process (TASEP). Inspired by experiments on the motion of kinesin-4 motors on ...

Traditionally, drug discovery programs are carried out by optimizing drug–target affinity and selectivity. Though tremendous progress has been made in this field, attrition rates in drug discovery ...