Effective and efficient protein purification processes are essential in drug discovery and development. Affinity fusion tags are commonly used in protein purification due to their ability to enable ...

Depending on the process and who provides the statistics, downstream processing accounts for between 50–80% of the cost of producing biotech drugs. Whatever the exact number, protein purification ...

Penn State chemical engineers have demonstrated proof of concept for a new protein purification process that combines ultrafiltration's high throughput with high specificity achievable through ...

One of the most expensive steps in manufacturing protein drugs such as antibodies or insulin is the purification step: isolating the protein from the bioreactor used to produce it. This step can ...

There are a wide variety of protein-based drugs that are used to treat various serious conditions. Insulin is perhaps the most well-known example, which is used for life-saving treatments for diabetes ...

The spike (S) glycoprotein of the pandemic virus, SARS-CoV-2, is a critically important target of vaccine design and therapeutic development. A high-yield, scalable, cGMP-compliant downstream process ...

Osteoporosis is characterized by low bone mass and abnormal skeletal architecture, which leads to impaired bone strength and an increased risk of fragility fractures 1,2. Approximately 20% of men and ...

Creating analytical tools that support the advancement of knowledge can often come about through the integration of existing information and techniques, theoretical and practical, directed toward a ...

Protein samples are essential to advance our understanding of disease pathways and develop new therapeutics. High-quality filtration is needed to protect purity, yield and functionality of target ...

Engineers devised a way to purify protein drugs during manufacturing. Their approach, which uses nanoparticles to rapidly crystallize proteins, could help make protein drugs more affordable and ...