The San Francisco 49ers host the Los Angeles Rams in a huge NFC West matchups. Here's the start time and where to watch.

Thursday Night Football schedule, TV channel, time, streaming information for San Francisco 49ers vs Los Angeles Rams NFL Week 5 game on Oct. 2, 2025.

The Rams vs. 49ers game kicks off at 4:25 p.m. ET/1:25 p.m. PT this Sunday, Nov. 9, 2025. The Week 10 game between the Rams and 49ers will air on FOX. Out-of-market, you can tune in via NFL Sunday Ticket on YouTube TV.

And the degree of difficulty remains high for the Rams even after the next two weeks. This is their schedule into the final stage of the season: Since San Francisco upset the Rams at home earlier this season, this is simply a must-win game for Los Angeles if they want to take the divisional crown in 2025.

The NFC West is loaded at the top, and two of the division's contenders meet on Sunday when the 6-3 San Francisco 49ers host the 6-2 Los Angeles Rams. This is the second meeting between these two rivals, as the 49ers won the Week 5 matchup 26-23 in overtime on Thursday Night Football.

The Los Angeles Rams are sitting nicely heading into their bye week at 5-2. Given that the Rams played teams like the San Francisco 49ers, Philadelphia Eagles, and Baltimore Ravens, 5-2 is not something to complain about. A serious argument can be made ...