The timely and unidirectional progression of the cell cycle is controlled by ubiquitin-mediated proteolysis of core components of the cell-cycle machinery. Two ubiquitin ligase complexes in particular ...
The completion of mitosis is governed by the dephosphorylation of cyclin-dependent kinase (Cdk) substrates and by the ubiquitination of anaphase-promoting complex (APC) substrates. The order in which ...
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