Too Old to Operate16d
ETV5-Mediated Transcriptional Repression of DDIT4 Blocks Macrophage Pro-Inflammatory Activation in Diabetic Atherosclerosis.
Atherosclerosis risk is elevated in diabetic patients, but the underlying mechanism such as the involvement of macrophages remains unclear. Here, we investigated the underlying mechanism related to ...
ALZFORUM5d
Expunging Microglial Lipid Droplets Boosts Phagocytosis
This adds to the growing body of work, from mouse and fly models, implicating lipid metabolism in neurodegeneration, particularly AD,” Amita Sehgal, Perelman School of Medici ...
GEN22d
Microglia May Also Be from Mars and Venus Notes New Study
“Microglia, the resident macrophages of the brain ... Male mice exhibited greater microglial depletion compared to females. Transcriptomic and flow cytometry analysis revealed sex-specific ...
ALZFORUM6d
From the Meninges, Regulatory T Cells Keep Brain Inflammation in Check
Stationed within the meninges, squads of immune cells lie in wait, ready to unleash an inflammatory assault within the brain if needed. Holding these trigger-happy troops back during peacetime falls ...
Q&A: Researcher discusses identifying new treatments for pediatric brain cancer
Rakesh Jain Ph.D., Director of the E.L. Steele Laboratories for Tumor Biology at Massachusetts General Hospital and A. Werk Cook Professor of Radiation Oncology at Harvard Medical School, is senior ...
gut.bmj9d
MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure
The temporal evolution of macrophage MerTK expression and its impact on resolution ... myeloid cells in areas of hepatic necrosis is contrasted by systemic immune cell depletion and dysregulation. Mer ...
Frontiers9d
The C-Type Lectin Receptor DC-SIGN Has an Anti-Inflammatory Role in Human M(IL-4) Macrophages in Response to Mycobacterium tuberculosis
Similar results in terms of DC-SIGN depletion and cell viability were obtained at 96, 120, and 144 h post-transfection (data not shown). Importantly, we noticed that DC-SIGN-depleted macrophages ...
eLife14d
Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1 + TAMs and CD8 + T cells
This important study provides solid evidence to support the anti-tumor potential of citalopram, originally an anti-depression drug, in hepatocellular carcinoma (HCC). In addition to their previous ...
thorax.bmj3d
Inflammation in preschool cystic fibrosis is of mixed phenotype, extends beyond the lung and is differentially modified by CFTR modulators
Background Early-life inflammation has long been recognised as a key pathophysiological process in the evolution of cystic ...
eLife2d
Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche
Megakaryocytes form a three-dimensional (3D) cage composed of laminin and collagen IV connected to the basement membrane surrounding them. This microarchitecture stabilizes megakaryocytes within their ...