Head coach Kyle Shanahan told reporters at a Monday press conference that running back Isaac Guerendo is going to miss will ...

The San Francisco 49ers added some running back depth to their roster ahead of their preseason opener vs. the Denver Broncos.

The 49ers have to come to grips that this running back is injury-prone and cannot be relied upon when the season begins.

The San Francisco 49ers signed running back Ke’Shawn Vaughn to a one-year deal ahead of their first preseason game against the Denver Broncos. Vaughn signed with the 49ers’ practice squad in August ...

McCaffrey is not in line to play in Saturday's preseason opener against the Broncos, Eric Branch of the San Francisco Chronicle and David Lombardi of SFStandard.com report. With Isaac Guerendo ...

San Francisco 49ers running back Jordan James did not suit up for the 49ers joint practice with the Denver Broncos. The ...

Injuries forced running back Isaac Guerendo and fullback Kyle Juszczyk out of Saturday’s practice at 49ers training camp.

Discover the top breakout running backs for 2025 fantasy football drafts, including Jordan Mason, Isaac Guerendo, and Omarion ...

Nearly 40 players are brand new to the 49ers’ roster and poised to make their debut in Saturday’s preseason opener against ...

Guerendo, 6-foot and 219 pounds, has 42 carries for 246 yards and two touchdowns, averaging a gaudy 5.9 yards per carry. His 15-yard run in the third quarter was the 49ers’ lone touchdown in a ...