eLife

Causal evidence for a domain-specific role of left superior frontal sulcus in human perceptual decision-making

Disrupting left superior frontal sulcus selectively impaired perceptual but not value-based decisions, revealing segregated prefrontal circuits for integrating sensory evidence versus subjective ...
eLife

Accelerated evolution in networked metapopulations of Pseudomonas aeruginosa

Centralized migration accelerates adaptation and drives parallel evolution, emphasizing the key influence of spatial organization on evolutionary dynamics across systems from pathogen transmission to ...
eLife

Identifying regulators of associative learning using a protein-labelling approach in Caenorhabditis elegans

An innovative and scalable proximity labelling method profiled proteins present in the Caenorhabditis elegans brain during learning, identifying known regulators as well as novel biological pathways.
eLife

Mast cells promote pathology and susceptibility in tuberculosis

Conserved mast-cell activation, marked by elevated protease expression, aligns with progressive tuberculosis across human, macaque, and murine models.
eLife

Executive resources shape the impact of language predictability across the adult lifespan

Analyses of self-paced reading times reveal that linguistic prediction deteriorates under limited executive resources, with this resource sensitivity becoming markedly more pronounced with advancing ...
eLife

Researchers grow specialised nerve cells that degenerate in ALS/motor neuron disease and are damaged in spinal cord injury

A research team has developed a way to produce a subset of highly specialised brain neurons that centrally degenerate in motor neuron disease and are damaged in spinal cord injury, laying foundations ...
eLife

Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi–Goutières syndrome neuropathology

A microglia replacement approach demonstrates that brain macrophages with patient mutations from Aicardi–Goutières syndrome, a genetic, brain predominant interferonopathy, are sufficient to drive ...
eLife

Human brain dynamics and spatiotemporal trajectories during threat processing

Intrinsic neural attractors and extrinsic environmental inputs jointly steer the dynamic trajectories of brain activity ...
eLife

Global risk mapping of highly pathogenic avian influenza H5N1 and H5Nx in the light of epidemic episodes occurring from 2020 onwards

Post-2020, highly pathogenic avian influenza H5 circulation is characterised by spatially expanded ecological suitability, changes in key environmental predictors, and a wider range of avian species ...
eLife

Cryo-EM structure revealed a novel F-actin binding motif in a Legionella pneumophila lysine fatty acyltransferase

A novel F-actin-binding motif consisting of an α-helix hairpin from a Legionella pneumophila lysine fatty acyltransferase has the potential to be developed as an F-actin probe.
eLife

TRPV3 channel activity helps cortical neurons stay active during fever

Developmental electrophysiological adaptations and heat-sensitive proteins, such as TRPV3, in cortical excitatory neurons help maintain stable activity levels when brain temperature rises by 2–3°C ...