Pancreatic cancer remains one of the most aggressive tumours with a 5-year survival rate of less than 5%. The dismal prognosis of this tumour entity that is associated with a high degree of drug ...

Lin Y, Pu S, Wang J et al . Pancreatic STAT5 activation promotes KrasG12D-induced and inflammation-induced acinar-to-ductal metaplasia … ...

Randomised controlled trials (RCTs) have shown that computer-aided detection (CADe) can significantly improve adenoma detection rates (ADRs). In contrast, implementation studies did not show ADR ...

Background Chronic inflammation and elevated reactive oxygen species are key contributors to hepatocellular carcinoma (HCC) progression. Objective This study aims to investigate the role of the ...

A high adenoma detection rate (ADR) is vital for effective colorectal cancer (CRC) screening, but evidence suggests limited additional benefit beyond a certain threshold. In a pooled analysis of five ...

In patients with small intestinal Crohn’s disease (CD), there is a need for a simple, non-invasive test to reduce dependence on invasive procedures (eg, enteroscopy) and costly imaging (eg, MRI or CT ...

Introduction Faecal Immunochemical Testing (FIT) is now a core step in the referral and investigation of patients presenting with symptoms of possible colorectal cancer (CRC), as concentrations of Hb ...

Background Liver metastasis is a major cause of mortality in patients with colorectal cancer (CRC). Understanding how CRC cells influence the formation of hepatic premetastatic niches (PMNs) is ...

The recent increase in our knowledge of human gut microbiota has changed our view on antibiotics. Antibiotics are, indeed, no longer considered only beneficial, but also potentially harmful drugs, as ...