Aortic stenosis (AS) has become the most frequent valvar heart disease and the most frequent cardiovascular disease after hypertension and coronary artery disease in Europe and North America. It ...

Background Abnormal microcirculation has been suggested in hearts with pathological conditions, particularly in hypertrophic hearts, even in the presence of normal epicardial coronary arteries.

Patients with ischaemic heart disease and low ejection fraction (EF) are at increased risk of sudden death. MADIT (Multicenter Automated Defibrillator Implantation Trial) II has shown that implantable ...

Introduction The clinical effectiveness of a ‘rule-out’ acute coronary syndrome (ACS) strategy for emergency department patients with chest pain, incorporating a single undetectable high-sensitivity ...

Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. It may cause symptoms such as palpitations, dyspnoea, fatigue, dizziness or chest discomfort. Mortality risk has been ...

We performed a systematic review of the current state of the literature regarding the natural history and outcomes of bicuspid aortic valve (BAV). PubMed and the reference lists of the included ...

Background Coarctation of the aorta (CoA) has good modern results, but large multicentre longitudinal data on outcomes, especially hospital resource utilisation through childhood and adolescence, are ...

In heart failure prognosis is related to the severity of impairment of functional capacity.1 The peak oxygen consumption (VO2) at cardiopulmonary exercise test (CPET) is considered the gold standard ...

In 1772, William Heberden described ‘a disorder of the breast marked with strong and peculiar symptoms… [with a] sense of strangling and anxiety’. Individuals affected are ‘seized while they are ...

Objectives His bundle pacing (HBP) can potentially correct left bundle branch block (LBBB). We aimed to assess the efficacy of HBP to correct LBBB and long-term clinical outcomes with HBP in patients ...

Methodology A literature review was carried out to analyse the effects of an increased intake of n3-PUFAs on vascular endothelial dysfunction. PubMed and SCOPUS were used to search for relevant ...

Background Physiology-guided coronary revascularisation is associated with better outcomes however it is unclear if pressure-derived indices, such as FFR, can reliably assess individual lesions in ...