Meredith and Derek started out as one-night stand lovers who eventually developed a complicated relationship with a great ...

Queen Shonda Rhimes — as she shall henceforth be called — is the ultimate master of the will-they-won't-they romance, making Ross and Rachel seem completely forgettable.

Despite what PEOPLE readers voted on for a landslide win, this PEOPLE writer has a few thoughts about who should be the ...

I’m certain there are plenty of Grey’s Anatomy fans who found it soul-crushing to hear Derek Shepherd say his final words when the trauma surgeon finally got to the hospital — “It’s too ...

Patrick Dempsey is an American actor. He is best known for his role as Derek "McDreamy" Shepherd on ABC's Grey's Anatomy (2005-2015, 2020-2021). He has also appeared in Sweet Home Alabama (2002 ...

Sydney Prescott — not to mention the hit teen dramedy Party of Five — breezes into Grey Sloan Memorial as Lizzle Shepherd, one of Derek's (Patrick Dempsey) many sisters. Lizzie's relationship ...