Cardiff University

Public Health

These blending-learning modules offer Continuing Professional Development (CPD) education to professionals, from a range of health and social care settings, the opportunity to explore high quality, ...
Europe PMC

Discovery of ZAP70 inhibitors by high-throughput docking into a conformation of its kinase domain generated by molecular dynamics.

Very few selective inhibitors of the zeta-chain associated protein kinase 70 kDa (ZAP70) have been reported despite its importance in autoimmune diseases. Here, to induce a fit of the so-called ...
Nature

A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity

After engagement of the T cell antigen receptor (TCR) by peptide-bound major histocompatibility complex molecules, the immunoreceptor tyrosine-based activation motifs in the CD3 and ζ-chains of the ...
scienceopen.com

Molecular mechanism of hepatitis C virus replicon variants with reduced susceptibility to a benzofuran inhibitor, HCV-796.

HCV-796 selectively inhibits hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. In hepatoma cells containing a genotype 1b HCV replicon, HCV-796 reduced HCV RNA levels by 3 to 4 log(10) HCV ...