Amid a handful of injuries in their running back room, the San Francisco 49ers are bolstering their backfield.

Head coach Kyle Shanahan told reporters at a Monday press conference that running back Isaac Guerendo is going to miss a ...

Running back Jeff Wilson is heading back to the 49ers. Wilson’s agents Drew Rosenhaus and Shaun O’Dare told ESPN that their ...

The San Francisco 49ers entered Saturday's game with just four running backs, and they lost one of them in the third quarter.

Injuries have been running rampant on the San Francisco 49ers since training camp began. They can’t even continue their kicker competition or have three quarter ...

San Francisco 49ers running back Jordan James did not suit up for the 49ers joint practice with the Denver Broncos. The ...

The San Francisco 49ers haven't had the best luck with injuries so far in training camp, as two more players are expected to be sidelined.

McCaffrey is not in line to play in Saturday's preseason opener against the Broncos, Eric Branch of the San Francisco Chronicle and David Lombardi of SFStandard.com report. With Isaac Guerendo ...

The San Francisco 49ers added some running back depth to their roster ahead of their preseason opener vs. the Denver Broncos.

Vaughn will solidify the 49ers' backfield depth due to Isaac Guerendo (shoulder) and Jordan James (finger) both being sidelined for a few weeks. Vaughn spent most of the 2024 season on the 49ers' ...

The 49ers are facing the Broncos in their first preseason game. Here are fiveplayers fans should keep their eyes on during ...

San Francisco 49ers running back Isaac Guerendo (shoulder) is expected to miss a couple of weeks, according to Matt Maiocco ...