Madness picks, predictions, odds for UC San Diego vs Michigan first-round South Region game on Thursday, March 20, 2025.

For the first time in three years, Michigan plays in the NCAA Tournament and their opponent is here for the first time.

Here is a complete guide to picking No. 5 Michigan vs. No. 12 UC San Diego in your 2025 March Madness bracket, including updated odds and our expert predictions for the South Region game.

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Basketball analyst Jay Bilas explained why he possible upsets in the NCAA Tournament games involving Michigan and Texas A&M.