Mitochondrial glutathione import via SLC25A39 supports breast cancer metastasis by linking glutathione availability to ATF4-driven integrated stress response signaling during early metastatic ...
1Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan. 2Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, ...
1Christopher S Bond Life Sciences Center, University of Missouri, Columbia, Missouri.
1Department of Biological Sciences, New York City College of Technology, City University of New York, Brooklyn, New York. 2Biology and Computer PhD Programs, The CUNY Graduate Center, City University ...
Abstract. Molecular glue degrader (MGD) is an emerging therapeutic strategy offering an exciting alternative to traditional small molecules exploring new target space. These small molecules interact ...
Abstract. TNG462 is a clinical-stage, MTA-cooperative PRMT5 inhibitor currently being evaluated in an ongoing phase I/II clinical trial for solid tumors with MTAP loss. Approximately 10-15% of all ...
Washington University In St. Louis, St. Louis, MO.
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Celltrion Pharm, Inc., Incheon, Republic of Korea.
Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
EXUMA Biotech Corp., West Palm Beach, FL.
SEMA3G binding to NRP1 suppresses cytotoxic T-cell activity to induce an immunosuppressive tumor microenvironment, positioning SEMA3G as a promising therapeutic target for improving cancer ...
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