Plants produce a wide diversity of compounds. Broadly, these are separated into primary metabolites, which are necessary for ...

Spatial metabolomics is transforming our understanding of microbial systems by uncovering the localized molecular dynamics ...

imageimageHDAC6 is upregulated in corneal diseases and causes ENKD1 deacetylation at lysine 98. Deacetylation of ENKD1 blocks its interaction with γ-tubulin and impairs its role in maintaining proper ...

MCM8 deficiency impairs meiotic homologous recombination repair, but the specific role of MCM8 in mitotic germ cells remains poorly understood. This study reveals that MCM8 interacts with helicase ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Fragmentomic features of circulating cell free ...

Dendritic cell (DC) dysfunction is known to exacerbate intestinal pathologies, but the mechanisms compromising DC-mediated immune regulation in this context remain unclear. Here, we show that ...

Thiol antioxidant dithiothreitol (DTT) is used as an endoplasmic reticulum (ER)‐specific stressor; however, its physiological effects beyond the ER remain obscurely defined. This study demonstrates ...

image image The GID E3 ligase utilizes swappable substrate receptors to maintain cellular homeostasis during distinct environmental perturbations. During heat stress, the substrate receptor Gid10 ...

The ER membrane protein SELENOT has been previously suggested to be neuroprotective, but its contribution to neuronal pathophysiology has not been thoroughly investigated. This study reports that ...

imageimagePatients with inflammatory arthritis face increased heart and lung complications, which current treatments fail to address. This study identifies a novel therapeutic approach by selective ...

Neural stem cells (NSCs) in the mammalian brain decline rapidly with age, leading to impairment of hippocampal memory function in later life. However, the relationship between epigenetic remodeling ...

Motile cells can use and switch between different modes of migration. Here, we use traction force microscopy and fluorescent labeling of actin and myosin to quantify and correlate traction force ...