Abstract: Objective: Magnetic resonance imaging (MRI) is an essential imaging modality in noninvasive splenomegaly diagnosis. However, it is challenging to achieve spleen volume measurement from three ...

80.2% of all patients included in the study were tested for Gaucher disease via β-glucocerebrosidase assay. Nonetheless, 22.3% of those with unexplained splenomegaly were not tested. Findings from the ...

Splenomegaly resulting from portal hypertension can be caused by cirrhosis, hepatic venous outflow tract obstruction and extrahepatic portal vein obstruction. Both cirrhosis and hepatic venous outflow ...

Myelofibrosis causes anemia, splenomegaly, and other symptoms, creating unmet treatment needs. The POIESIS trial explores navtemadlin as an add-on to Jakafi for suboptimal responders. Navtemadlin ...

Setting realistic expectations about transfusion burden reduction rather than promising complete independence Goals include: fewer transfusions, reduced infusion center visits, delayed iron overload ...

CALR-mutated myelofibrosis patients often present with more severe disease and require more innovative therapies for better long-term outcomes. Jakafi shows initial benefits, but CALR-mutated patients ...

2 Attikon University Hospital and Joint Rheumatology Program, National and Kapodistrian University of Athens, 4th Department of Internal Medicine, Athens, Greece 3 Hippokration General Hospital, 2nd ...

Source: Getty Images Primary myelofibrosis is a rare cancer. In the United States (US), the annual incidence is approximately 0.3 cases per 100,000 individuals. The median age of patients with primary ...

CLL symptoms tend to be mild at first and progress slowly. 4 These symptoms can include lymphadenopathy, splenomegaly, hepatomegaly, shortness of breath and anemia, fatigue and weakness, frequent ...

The National Institute for Health and Care Excellence (NICE) has recommended fedratinib (Inrebic) for treating disease-related splenomegaly or symptoms of primary myelofibrosis, post-polycythemia vera ...